It happened around 3:00pm in the Eastbound lands of I-10 between the Michigan Avenue and Broad Street exits.
Police say a Ford Explorer and a Ford Focus collided while one of the vehicles was attempting to change lanes.
The Explorer flipped several times, ejecting and killing the driver.
Police say 6 passengers were injured and taken to USA Medical Center for treatment of non-life threatening injuries.
According to officers, the driver of the Focus was not hurt.
Stacy Grandberg came up on the accident scene shortly after it happened and jumped out to help. "We could see people running in a panic, I got out because I have a nursing history.Obviously there's fatalities on the road that were out of the vehicle. There were young children crying and screaming and one young little boy laying right here that's very hurt very hurt. Most of them I think are O.K."
The cause of the accident remains under investigation.
The names of those involved have not been released.
Wreck On I-10 Backs Up Traffic Across Mobile Bay










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